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KMID : 0357919850190040391
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Korean Journal of Pathology
1985 Volume.19 No. 4 p.391 ~ p.401
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Immunohistochemical Studies on the Serotonin, Somatostatin and Gastrin-Positive Cells in the Gastric Adenocarcinoma
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Abstract
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In order to study the histogenesis of gastric carcionma, and to find the correlationship
between the gastric carcinoma and endocrine tumor of digestive tract, we performed
immunoperoxidase staining for serotonin, somatostatin and gastrin respectively in the 34
cases of surgically resected gastric carcinoma The results were as follows ;
1) Endocrine fells were found in 26.5 % (9/34) of the gastric adenocarcinoma, but in
58.6% (17/29) in the normal gastric mucosa near the cancer area. The occurence of
endocrine cells was less frequent in cancer than in the normal gastric mucosa.
2) Among the If cases of intestinal type adenocarcinoma, serotonin-positive cells were
found in 2 cases, somatostatin-positive cells in 1 case and gastrin-positive cells in 1
case. Among 16 case of diffuse type ade-nocarcinoma, gastrin-positive cells were found
in 2 cases, and somatostatin-positive cells were found in 2 cases.
3) We concluded that, the endocrine cells are more frequently observed in the well
differentiated gastric carcinoma than poorly differentiated carcinoma tissue.
In summary, gastric carcinomas are supposed to arise from the totipotent stem cells
of endoderm origin, and they have multidirectional property of differentiation into both
endocrine and nonendocrine cells. Most of them differentiate into nonendocrine cells and
only a few of them differentiate into endocrine cells.
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